Vol. 7, Issue 2, Part A (2025)

The present study explores the formulation and evaluation of a transdermal film incorporating the methanolic extract of Piper betle (betel leaf), aimed at delivering a natural anti-inflammatory agent through the skin. Given the traditional medicinal importance of Piper betle, especially its analgesic and anti-inflammatory properties, the extract was selected for incorporation into a hydroxypropyl methylcellulose (HPMC)-based transdermal patch. Preformulation studies, including phytochemical screening, FTIR analysis, and solubility determination, confirmed the presence of bioactive compounds and compatibility with excipients. The formulated films were characterized for physicochemical parameters such as thickness, moisture content, pH, and drug content. Additionally, anti-inflammatory activity was assessed using the egg albumin denaturation assay, with results showing 65.70% inhibition, close to the standard drug aspirin. The findings suggest that the herbal transdermal film delivers a stable, biocompatible, and effective anti-inflammatory effect, with potential for further development in the management of localized inflammation and pain.