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International Journal of Pharmacognosy and Pharmaceutical Research

Vol. 7, Issue 1, Part A (2025)

Synergistic antibacterial efficacy of Aloe Vera and Cymbopogon Citratus extracts for treating skin infections

Author(s):

Abimbola D Sola-Aremu and Abiodun John Ologunowa

Abstract:

Skin infections caused by bacterial pathogens represent a significant health challenge, exacerbated by the rise in antimicrobial resistance (AMR) to commonly used antibiotics. AMR is a major global public health threat, with skin infections increasingly impacted. This study evaluates the antibacterial efficacy of Aloe Vera gel and Cymbopogon Citratus essential oil, individually and in combination, as a topical herbal formulation for skin infections. Plant specimens were collected, authenticated, and processed to extract Cymbopogon Citratus oil and Aloe Vera gel. Minimum inhibitory concentration (MIC) values were determined using agar plate methods against bacterial strains, including Staphylococcus aureus 6571, Escherichia coli 2592 and 700728, Bacillus cereus, and Pseudomonas aeruginosa 27853 and 31. Herbal cream formulations were assessed for spreadability, stability, and homogeneity. The MIC of Aloe Vera gel alone was >6.67% v/v for all tested strains, while Cymbopogon Citratus oil exhibited strong antibacterial activity with MIC <0.4% v/v for most strains, except P. aeruginosa 31 (0.83% v/v). The combination of Aloe Vera gel and Cymbopogon Citratus oil demonstrated enhanced activity, with MIC <0.4% v/v for most strains but increased to 1.67% v/v for P. aeruginosa 31, suggesting potential synergistic effects. The Aloe Vera and Cymbopogon Citratus formulation offers promising antibacterial activity and skin-healing benefits, supporting its role in addressing AMR in dermatological care. Further optimization is required to enhance its efficacy against resistant strains like P. aeruginosa 31.

Pages: 01-05  |  93 Views  41 Downloads


International Journal of Pharmacognosy and Pharmaceutical Research
How to cite this article:
Abimbola D Sola-Aremu and Abiodun John Ologunowa. Synergistic antibacterial efficacy of Aloe Vera and Cymbopogon Citratus extracts for treating skin infections. Int. J. Pharmacogn. Pharm. Res. 2025;7(1):01-05. DOI: 10.33545/26647168.2025.v7.i1a.86
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