Vol. 5, Issue 1, Part A (2023)

Today, several plant extracts are employed as chemoprophylactics for a variety of illnesses. This is mainly because they are less restrictive, easily accessible, and extremely economical, and they are also known to contain bioactive components with antimalarial activities. The dosage of these extracts is typically not carefully controlled, which causes individuals to suffer serious harm to several important organs damage including the liver. Therefore, the present study aimed to determine the histopathological impact of Mangifera indica aqueous extract on the liver of the experimental rats. The mango leaves were collected and identified at the herbarium of the Botany Department, Gombe State University with voucher number GSUH46. The identified leaves were washed with distilled water and dried under shade at optimal ventilation for one week, after which it was crushed into labelled powder using electric blender. One hundred and fifty grams (150 g) of the sample was socked in 2 litres of distilled water for the extraction of the phytochemical components of the leaves using standard technique and the doses of the extract to be administered were determined according to the body weight of the experimental animals. For the oral acute toxicity test, five (5) albino rats were treated with 2000 mg/kg of the extract and monitored for any physical signs of toxic manifestations. The liver of two rats from each group was dissected and examined for morphological and histological changes. The morphological examination of the livers shows no morphological or histological difference. Mangifera indica aqueous extract is safe to be used as it has no effect on the liver of treated rat.