Abstract:Now a days, Novel Drug Delivery System is most commonly used technique for the optimum understanding of Pharmacokinetic and Pharmacodynamic of any Drug. NDDS is a kind of system through which pharmaceutical compound is transported to the targeted location at right time in a required amount for optimum result. Phytosome is Novel Drug Delivery System results from the reaction of phospholipid and natural active ingredient which are extracted from natural sources. Phytosomes are used to increase the absorption of any drug especially lipid in-soluble drug orally as well as topically. Phytosomes are used to encapsulate various drug complexes and naturally isolated nutraceutical such as polyphenolic compounds, flavonoid and many more.