Contact: +91-9711224068
  • Printed Journal
  • Indexed Journal
  • Refereed Journal
  • Peer Reviewed Journal
International Journal of Pharmacognosy and Pharmaceutical Research

Vol. 1, Issue 1, Part A (2019)

Anti-inflammatory, Anti-Nociceptive and antipyretic activity of Acalypha wilkesiana hydro-methanolic leave extract: A non-invasive investigation

Author(s):

Ilochi ON, Aniyeloye MA, Chuemere AN, Bassey SE

Abstract:

Acalypha wilkesiana is an evergreen shrub usually planted around homes for horticultural purposes. This study investigated the potential ameliorating effect of A. wilkesiana leaf extract in inflammatory, pyretic and pain-induced conditions. Sixty five (65) male wistar rats with average weight of 205 grams were sampled randomly in three separate treatment protocols. First treatment include 5 groups a to e administered Normal saline, aspirin (0.9mg/ml), 40mg/kg-AW, 80 mg/kg-AW, 160 mg/kg-AW respectively; second and third treatments a to e were; Normal saline, Piroxicam, 40mg/kg-AW, 80 mg/kg-AW, 160 mg/kg-AW respectively. The extract caused significant changes (P<0.05) similar to aspirin and piroxicam on pyrexia and inflammation, but showed no tendency of ameliorating pain. From this investigation, A. wilkesiana leaf extract has significant anti-inflammatory and anti-pyretic phytotherapeutic tendency, and this effect may be dependent on the dose of treatment.

Pages: 01-04  |  1635 Views  703 Downloads

How to cite this article:
Ilochi ON, Aniyeloye MA, Chuemere AN, Bassey SE. Anti-inflammatory, Anti-Nociceptive and antipyretic activity of Acalypha wilkesiana hydro-methanolic leave extract: A non-invasive investigation. Int. J. Pharmacogn. Pharm. Res. 2019;1(1):01-04. DOI: 10.33545/26647168.2019.v1.i1a.19
International Journal of Pharmacognosy and Pharmaceutical Research

International Journal of Pharmacognosy and Pharmaceutical Research