International Journal of Pharmacognosy and Pharmaceutical Research
2019, Vol. 1, Issue 1
Anti-inflammatory, Anti-Nociceptive and antipyretic activity of Acalypha wilkesiana hydro-methanolic leave extract: A non-invasive investigation
Ilochi ON, Aniyeloye MA, Chuemere AN, Bassey SE
Acalypha wilkesiana is an evergreen shrub usually planted around homes for horticultural purposes. This study investigated the potential ameliorating effect of A. wilkesiana leaf extract in inflammatory, pyretic and pain-induced conditions. Sixty five (65) male wistar rats with average weight of 205 grams were sampled randomly in three separate treatment protocols. First treatment include 5 groups a to e administered Normal saline, aspirin (0.9mg/ml), 40mg/kg-AW, 80 mg/kg-AW, 160 mg/kg-AW respectively; second and third treatments a to e were; Normal saline, Piroxicam, 40mg/kg-AW, 80 mg/kg-AW, 160 mg/kg-AW respectively. The extract caused significant changes (P<0.05) similar to aspirin and piroxicam on pyrexia and inflammation, but showed no tendency of ameliorating pain. From this investigation, A. wilkesiana leaf extract has significant anti-inflammatory and anti-pyretic phytotherapeutic tendency, and this effect may be dependent on the dose of treatment.